Affiliation:
1. Renal Research Group, Kolling Institute, St. Leonards, NSW 2065, Australia
Abstract
The developmental programming hypothesis proposes that adverse environmental insults during critical developmental periods increase the risk of diseases later in life. The kidneys are deemed susceptible to such a process, although the exact mechanisms remain elusive. Many factors have been reported to contribute to the developmental origin of chronic kidney diseases (CKD), among which peri-gestational nutrition has a central role, affecting kidney development and metabolism. Physiologically, the link between malnutrition, reduced glomerular numbers, and increased blood pressure is key in the developmental programming of CKD. However, recent studies regarding oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes have revealed potential novel pathways for therapeutic intervention. This review will discuss the role of imbalanced nutrition in the development of CKD.
Subject
Food Science,Nutrition and Dietetics
Reference131 articles.
1. Developmental origins of health and disease;Gillman;N. Engl. J. Med.,2005
2. Sirtuins-mediators of maternal obesity-induced complications in offspring?;Nguyen;FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.,2016
3. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales;Barker;Lancet,1986
4. Weight in infancy and death from ischaemic heart disease;Barker;Lancet,1989
5. Glomeruli and blood pressure. Less of one, more the other?;Brenner;Am. J. Hypertens.,1988