Abstract
Atherosclerosis and its clinical manifestations, coronary and cerebral artery diseases, are the most common cause of death worldwide. The main pathophysiological mechanism for these complications is the rupture of vulnerable atherosclerotic plaques and subsequent thrombosis. Pathological studies of the vulnerable lesions showed that more frequently, plaques rich in lipids and with a high level of inflammation, responsible for mild or moderate stenosis, are more prone to rupture, leading to acute events. Identifying the vulnerable plaques helps to stratify patients at risk of developing acute vascular events. Traditional imaging methods based on plaque appearance and size are not reliable in prediction the risk of rupture. Intravascular imaging is a novel technique able to identify vulnerable lesions, but it is invasive and an operator-dependent technique. This review aims to summarize the current data from literature regarding the main biomarkers involved in the attempt to diagnose vulnerable atherosclerotic lesions. These biomarkers could be the base for risk stratification and development of the new therapeutic drugs in the treatment of patients with vulnerable atherosclerotic plaques.
Funder
Iuliu Hatieganu University of Medicine, Cluj-Napoca
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference197 articles.
1. Atherosclerosis: Recent developments;Björkegren;Cell,2022
2. Quest for Novel Cardiovascular Biomarkers by Proteomic Analysis;Vivanco;J. Proteome Res.,2005
3. Vascular proteomics in metabolic and cardiovascular diseases;Lynch;J. Intern. Med.,2016
4. Hypoalbuminemia—Prognostic factor for the short-term evolution of patients with unstable angina;Chiorescu;Hum. Vet. Med.,2017
5. Endothelial dysfunction as a cellular mechanism for vascular failure;Hirase;Am. J. Physiol. Circ. Physiol.,2012
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