Affiliation:
1. Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Pretoria 0031, South Africa
Abstract
Immune checkpoint inhibitors (ICIs) are a class of immunotherapy agents capable of alleviating the immunosuppressive effects exerted by tumorigenic cells. The programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint is one of the most ubiquitous checkpoints utilized by tumorigenic cells for immune evasion by inducing apoptosis and inhibiting the proliferation and cytokine production of T lymphocytes. Currently, the most frequently used ICIs targeting the PD-1/PD-L1 checkpoint include monoclonal antibodies (mAbs) pembrolizumab and nivolumab that bind to PD-1 on T lymphocytes and inhibit interaction with PD-L1 on tumorigenic cells. However, pembrolizumab and nivolumab are costly, and thus their accessibility is limited in low- and middle-income countries (LMICs). Therefore, it is essential to develop novel biomanufacturing platforms capable of reducing the cost of these two therapies. Molecular farming is one such platform utilizing plants for mAb production, and it has been demonstrated to be a rapid, low-cost, and scalable platform that can be potentially implemented in LMICs to diminish the exorbitant prices, ultimately leading to a significant reduction in cancer-related mortalities within these countries.
Funder
Cancer Association of South Africa
Medical Research Council
Struwig Germeshuysen Trust
School of Medicine Research Committee of the University of Pretoria
South African National Research Foundation
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference121 articles.
1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021
2. (2023, February 19). Cancer. Available online: https://www.who.int/news-room/fact-sheets/detail/cancer.
3. Mattila, P.O., Babar, Z.-U.-D., and Suleman, F. (2021). Assessing the Prices and Affordability of Oncology Medicines for Three Common Cancers within the Private Sector of South Africa. BMC Health Serv. Res., 21.
4. Integrative Oncology: Addressing the Global Challenges of Cancer Prevention and Treatment;Mao;CA Cancer J. Clin.,2022
5. Starvation, Stress Resistance, and Cancer;Buono;Trends Endocrinol. Metab.,2018
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