The Brain at High Altitude: From Molecular Signaling to Cognitive Performance-Reference-Cited by-全球学者库

The Brain at High Altitude: From Molecular Signaling to Cognitive Performance

Published:2023-06-15 Issue:12 Volume:24 Page:10179
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Aboouf Mostafa A.¹²³^ORCID,Thiersch Markus¹³^ORCID,Soliz Jorge⁴,Gassmann Max¹³^ORCID,Schneider Gasser Edith M.¹⁴⁵^ORCID

Affiliation:

1. Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zürich, 8057 Zurich, Switzerland

2. Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

3. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland

4. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Faculty of Medicine, Université Laval, Québec, QC G1V 4G5, Canada

5. Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland

Abstract

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims to summarize the cellular, metabolic, and functional alterations in the brain at HA with a focus on the role of hypoxia-inducible factors in controlling the hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, and plasticity.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/12/10179/pdf

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