The Role of EMT-Related lncRNAs in Ovarian Cancer-Reference-Cited by-同舟云学术

The Role of EMT-Related lncRNAs in Ovarian Cancer

Published:2023-06-13 Issue:12 Volume:24 Page:10079
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Lampropoulou Dimitra Ioanna¹^ORCID,Papadimitriou Marios²³,Papadimitriou Christos³^ORCID,Filippou Dimitrios⁴⁵^ORCID,Kourlaba Georgia⁶,Aravantinos Gerasimos⁷,Gazouli Maria⁸^ORCID

Affiliation:

1. ECONCARE LP, Health Research & Consulting, 11528 Athens, Greece

2. Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA

3. Second Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

4. Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

5. National Organization for Medicines (EOF), 15562 Athens, Greece

6. Department of Nursing, University of Peloponnese, 22100 Tripoli, Greece

7. Euroclinic, Athanasiadou 7-9, 11521 Athens, Greece

8. Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

Abstract

Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/12/10079/pdf

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