Reagentless Glucose Biosensor Based on Combination of Platinum Nanostructures and Polypyrrole Layer-Reference-Cited by-同舟云学术

Reagentless Glucose Biosensor Based on Combination of Platinum Nanostructures and Polypyrrole Layer

Published:2024-03-04 Issue:3 Volume:14 Page:134
ISSN:2079-6374
Container-title:Biosensors
language:en
Short-container-title:Biosensors

Author:

German Natalija¹^ORCID,Popov Anton¹²^ORCID,Ramanaviciene Almira¹²^ORCID

Affiliation:

1. Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Santariskiu 5, LT-08406 Vilnius, Lithuania

2. NanoTechnas—Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 243, LT-03225 Vilnius, Lithuania

Abstract

Two types of low-cost reagentless electrochemical glucose biosensors based on graphite rod (GR) electrodes were developed. The electrodes modified with electrochemically synthesized platinum nanostructures (PtNS), 1,10-phenanthroline-5,6-dione (PD), glucose oxidase (GOx) without and with a polypyrrole (Ppy) layer—(i) GR/PtNS/PD/GOx and (ii) GR/PtNS/PD/GOx/Ppy, respectively, were prepared and tested. Glucose biosensors based on GR/PtNS/PD/GOx and GR/PtNS/PD/GOx/Ppy electrodes were characterized by the sensitivity of 10.1 and 5.31 μA/(mM cm2), linear range (LR) up to 16.5 and 39.0 mM, limit of detection (LOD) of 0.198 and 0.561 mM, good reproducibility, and storage stability. The developed glucose biosensors based on GR/PtNS/PD/GOx/Ppy electrodes showed exceptional resistance to interfering compounds and proved to be highly efficient for the determination of glucose levels in blood serum.

Publisher

MDPI AG

Link

https://www.mdpi.com/2079-6374/14/3/134/pdf

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