Abstract
Oral microbiota formation begins from birth, and everything from genetic components to the environment, alongside the host’s behavior (such as diet, smoking, oral hygiene, and even physical activity), contributes to oral microbiota structure. Even though recent studies have focused on the gut microbiota’s role in systemic diseases, the oral microbiome represents the second largest community of microorganisms, making it a new promising therapeutic target. Periodontitis and dental caries are considered the two main consequences of oral bacterial imbalance. Studies have shown that oral dysbiosis effects are not limited locally. Due to technological advancement, research identified oral bacterial species in heart valves. This evidence links oral dysbiosis with the development of valvular heart disease (VHD). This review focuses on describing the mechanism behind prolonged local inflammation and dysbiosis, that can induce bacteriemia by direct or immune-mediated mechanisms and finally VHD. Additionally, we highlight emerging therapies based on controlling oral dysbiosis, periodontal disease, and inflammation with immunological and systemic effects, that exert beneficial effects in VHD management.
Subject
Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics
Reference138 articles.
1. Thomas, C., Minty, M., Vinel, A., Canceill, T., Loubières, P., Burcelin, R., Kaddech, M., Blasco-Baque, V., and Laurencin-Dalicieux, S. (2021). Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases. Diagnostics, 11.
2. Oral microbiome: Unveiling the fundamentals;Deo;J. Oral Maxillofac. Pathol. JOMFP,2019
3. Human oral microbiota and its modulation for oral health;Zhang;Biomed. Pharmacother.,2018
4. The Oral Microbiota Is Modified by Systemic Diseases;Grves;J. Dent. Res.,2018
5. Periodontitis: From microbial immune subversion to systemic inflammation;Hajishengallis;Nat. Rev. Immunol.,2015
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献