Investigating the Influence of High-Speed Gantry Rotation in Cardiac CT on Motion Artifacts in Aortic Stenosis Patients Not Premedicated with β-Blockers: The FAST-CCT Randomized Trial Protocol

Author:

Fahrni Guillaume1ORCID,Gullo Giuseppe1,Touray Aisha1,Fournier Stéphane2,Jouannic Anne-Marie1,Lu Henri2ORCID,Racine Damien3,Muller Olivier2ORCID,Pozzessere Chiara1ORCID,Qanadli Salah D.45,Rotzinger David C.1ORCID

Affiliation:

1. Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland

2. Department of Cardiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland

3. Institute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Rue du Grand-Pré 1, 46, 1007 Lausanne, Switzerland

4. Riviera-Chablais Hospital, Rte du Vieux Séquoia 20, 1847 Rennaz, Switzerland

5. Faculty of Biology and Medicine (FBM), University of Lausanne, 1015 Lausanne, Switzerland

Abstract

Background: Coronary CT angiography (CCTA) is increasingly used as a non-invasive tool to assess coronary artery disease (CAD). However, CCTA is subject to motion artifacts, potentially limiting its clinical utility. Despite faster (0.35 and 0.28 s/rot) gantry rotation times, low (60–65 bpm) heartbeat is recommended, and the use of β-blockers is often needed. Technological advancements have resulted in the development of faster rotation speeds (0.23 s/rot). However, their added value in patients not premedicated with β-blockers remains unclear. This prospective single-center, two-arm, randomized, controlled trial aims to assess the influence of fast rotation on coronary motion artifacts, diagnostic accuracy of CCTA for CAD, and patient safety. Methods: We will randomize a total of 142 patients aged ≥ 50 scheduled for an aortic stenosis work-up to receive CCTA with either a fast (0.23) or standard (0.28 s/rot) gantry speed. Primary outcome: rate of CCTAs with coronary motion artifacts hindering interpretation. Secondary outcomes: assessable coronary segments rate, diagnostic accuracy against invasive coronary angiography (ICA), motion artifact magnitude per segment, contrast-to-noise ratio (CNR), and patient ionizing radiation dose. The local ethics committee has approved the protocol. Potential significance: FAST-CCT may improve motion artifact reduction and diagnosis quality, thus eliminating the need for rate control and β-blocker administration. Clinicaltrials.gov identifier: NCT05709652.

Publisher

MDPI AG

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Reference29 articles.

1. (2023, July 29). Underlying Cause of Death, 1999–2019 Request, Available online: https://wonder.cdc.gov/ucd-icd10.html.

2. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association;Jordan;Circulation,2019

3. The history of cardiac catheterization;Bourassa;Can. J. Cardiol.,2005

4. Carpeggiani, C., Picano, E., Brambilla, M., Michelassi, C., Knuuti, J., Kauffman, P., Underwood, S.R., Neglia, D., and EVINCI Study Investigators (2017). Variability of radiation doses of cardiac diagnostic imaging tests: The RADIO-EVINCI study (RADIationdOse subproject of the EVINCI study). BMC Cardiovasc. Disord., 17.

5. Coronary CT angiography;Schoepf;Radiology,2007

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