Rehabilitation Exercises Supported by Monitor-Augmented Reality for Patients with High-Grade Glioma Undergoing Radiotherapy: Results of a Randomized Clinical Trial

Author:

Pieczyńska Anna12ORCID,Zasadzka Ewa1ORCID,Pilarska Agnieszka2,Procyk Danuta3,Adamska Krystyna45,Hojan Katarzyna12ORCID

Affiliation:

1. Department of Occupational Therapy, Poznan University of Medical Sciences, 61-781 Poznan, Poland

2. Department of Rehabilitation, Greater Poland Cancer Centre, 61-866 Poznan, Poland

3. Central Laboratory, Greater Poland Cancer Centre, 15, 61-866 Poznan, Poland

4. Chair and Department of Electroradiology, Poznan University of Medical Science, 61-781 Poznan, Poland

5. 3rd Radiotherapy Department, Greater Poland Cancer Centre, 61-866 Poznan, Poland

Abstract

Background: Exercise has been shown to improve quality of life (QoL) and even treatment outcomes in cancer patients. However, the evidence to support the benefits of exercise in patients with high-grade glioma (HGG) is limited. Therefore, we performed a randomized clinical trial (RCT) to examine the effect of augmented-reality-based rehabilitation exercises on physical and functional fitness, cognitive function, fatigue, mood, QoL, selected blood parameters, brain derived neurotrophic factor (BDNF), and S100 protein in patients with HGG. Methods: Adult patients with HGG scheduled to undergo radiotherapy after tumor resection were randomized to participate in an exercise program (experimental group, n = 25) or to receive usual care (controls, n = 22). Physical and mental fitness was measured at baseline, after the completion of radiotherapy, and at 3 months. The following tests were administered: Handgrip Strength Test; 6-Minute Walk Test; Time Up and Go test; Functional Independent Measure scale; Addenbrooke’s Cognitive Examination III (ACE III); Hospital Anxiety and Depression Scale; Functional Cancer Therapy Assessment—Brain; and Functional Assessment of Chronic Illness Therapy—Fatigue. We also measured blood parameters, BDNF, and S100 protein levels. Results: No significant changes were observed in the exercise group. However, the controls experienced a significant decrease in HGS and in the ACE III attention domain. No significant changes were observed in QoL, fatigue, BDNF, or S100 levels in either group. Conclusions: Augmented-reality-based exercise during radiation therapy may prevent loss of muscle strength and attention in patients with HGG.

Funder

National Science Center

Publisher

MDPI AG

Subject

General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Exercise intervention may play a potential therapeutic role in patients with glioblastoma multiforme (Review);World Academy of Sciences Journal;2024-06-20

2. Glioblastoma: quality of life as a key element in evaluation of radiation treatment effectiveness;Український радіологічний та онкологічний журнал;2024-03-22

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