Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review

Author:

Pechlivanidou Evmorfia12ORCID,Chatzikyriakos Alexandros1,Zisi Maria Anna3,Paraskevopoulos Nikolaos1,Kaltsa Semeli1,Konstantas Orestis K.1,Zogakis Panteleimon1,Catsouli Aikaterini1,Sekouris Nick1,Margariti Rodanthi E.1

Affiliation:

1. 1st Department of Orthopaedics, P. & A. Kyriakou Children’s Hospital, 115 27 Athens, Greece

2. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece

3. Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece

Abstract

This literature review, in light of the presented case report, explores the complex interplay between gabapentin (GBP), a gamma-aminobutyric acid (GABA) analog, and the hypothalamic–pituitary–adrenal (HPA) axis in patients undergoing major surgical procedures. It specifically investigates the potential impact of GBP on cortisol levels, stress responses, and infection risk, illustrated by a detailed clinical case. This review combines a comprehensive literature search with a case report of a 17-year-old male with osteosarcoma who experienced transient adrenal insufficiency and infections while receiving GBP. The case is analyzed in the context of the existing literature on GBP and the HPA axis. The findings highlight the intricate relationship between GBP use, adrenal insufficiency, and infection susceptibility. It underscores the need for further research and clinical vigilance when prescribing GBP to patients with underlying medical conditions, particularly in the context of major surgical procedures. The review underscores the need for further research and clinical vigilance when prescribing GBP, particularly in perioperative settings. In conclusion, GBP’s effects on the HPA axis and immune responses are complex and multifaceted. Clinicians should exercise caution when prescribing GBP, especially for patients with underlying conditions undergoing major surgery. Further research is needed to elucidate the mechanisms of GBP’s influence on cortisol levels and stress responses.

Publisher

MDPI AG

Reference36 articles.

1. Patient Case Report: Gabapentin-Induced Hypoglycemia;Hayes;J. Pharm. Pract.,2022

2. (2010). Product Information. Neurontin(R) Oral Capsules, Tablets, Solution, Gabapentin Oral Capsules, Tablets, Solution, Food and Drug Administration.

3. Mechanisms of action of gabapentin;Taylor;Rev. Neurol.,1997

4. A summary of mechanistic hypotheses of gabapentin pharmacology;Taylor;Epilepsy Res.,1998

5. Central Neuropathic Pain Syndromes: Current and Emerging Pharmacological Strategies;Gurba;CNS Drugs,2022

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3