Abstract
Many studies have documented that dental diseases were associated with an increased risk of cardiovascular diseases. Aortic arch calcification (AoAC) is a powerful predictor of cardiovascular diseases. However, whether the status of dental health is associated with AoAC is still unknown. 9463 participants over the age of 60 from Shenzhen community centers were included in the cross-sectional analysis. Physical examination data, blood biochemical tests, and AoAC scores calculated by chest radiography were collected and analyzed. Among them, 2630 participants were followed up for AoAC progression up to 36 months. Participants with AoAC suffered more tooth loss than those without AoAC (77.62% vs. 72.91%; p < 0.001). Association rule analysis suggested a strong association between dental diseases and AoAC. Tooth loss or decay increased the risk of AoAC progression (HR 1.459; 95%CI 1.284–1.658) after adjusting other risk factors including renal dysfunction. Dental diseases are potential predictors for AoAC in elderly people, which are independent of renal dysfunction.
Funder
National Key Research and Development Program
National Nature Science Foundation of China
Central Military Commission Key Project of Basic Research for Application
Regional Joint Funding Key Project of Guangdong Basic Research and Basic Research for Application
Key Project of Sustainable Development Science and Technology of Shenzhen Science and Technology Innovation Committee
Basic Research Project of Shenzhen Science and Technology Innovation Committee
Shenzhen Key Medical Discipline Construction Fund
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism