Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed

Author:

Di Paola Rossella1,De Ananya1ORCID,Capasso Anna2,Giuliana Sofia3,Ranieri Roberta3,Ruosi Carolina3,Sciarra Antonella4,Vitagliano Caterina3,Perna Alessandra F.5ORCID,Capasso Giovambattista6,Simeoni Mariadelina5ORCID

Affiliation:

1. Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

2. Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas, Austin, TX 75063, USA

3. Nephrology Unit, Department of Specialist General Surgery, University Hospital “Luigi Vanvitelli”, 80131 Naples, Italy

4. Department of Oncologic Surgery, Translational Medical Sciences at University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

5. Nephrology and Dialysis Unit, Department of Translational Medical Sciences at University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

6. Biogem S.c.a.r.l. Research Institute, 83031 Ariano Irpino, Italy

Abstract

Thyroid cancers require complex and heterogeneous therapies with different impacts on renal function. In our systematic literature review, we analyzed several aspects: renal function assessment, the impact of radiotherapy and thyroid surgery on kidney functioning, and mechanisms of nephrotoxicity of different chemotherapy, targeted and immunologic drugs. Our study revealed that the renal impact of thyroid cancer therapy can be a limiting factor in all radiotherapy, surgery, and pharmacological approaches. It is advisable to conduct a careful nephrological follow-up imposing the application of body surface based estimated Glomerular Filtration Rate (eGFR) formulas for the purpose of an early diagnosis and treatment of renal failure, guaranteeing the therapy continuation to thyroid cancer patients.

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

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