Genomic Sequencing Profiles of Mycobacterium tuberculosis in Mandalay Region, Myanmar-Reference-Cited by-全球学者库

Genomic Sequencing Profiles of Mycobacterium tuberculosis in Mandalay Region, Myanmar

Published:2023-04-21 Issue:4 Volume:8 Page:239
ISSN:2414-6366
Container-title:Tropical Medicine and Infectious Disease
language:en
Short-container-title:TropicalMed

Author:

Phyu Aye Nyein¹²^ORCID,Aung Si Thu³,Palittapongarnpim Prasit⁴^ORCID,Htet Kyaw Ko Ko²^ORCID,Mahasirimongkol Surakameth⁵,Ruangchai Wuthiwat⁴,Jaemsai Bharkbhoom⁴,Aung Htin Lin⁶,Maung Htet Myat Win²^ORCID,Chaiprasert Angkana⁷,Pungrassami Petchawan⁸^ORCID,Chongsuvivatwong Virasakdi²^ORCID

Affiliation:

1. National Tuberculosis Programme, Department of Public Health, Ministry of Health, Mandalay 05071, Myanmar

2. Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai 90110, Thailand

3. Department of Public Health, Ministry of Health, Keng Tung 06231, Myanmar

4. Pornchai Matangkasombut Center for Microbial Genomics, Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

5. Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand

6. Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand

7. Office of Research and Innovation, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

8. Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand

Abstract

This study aimed to characterize whole-genome sequencing (WGS) information of Mycobacterium tuberculosis (Mtb) in the Mandalay region of Myanmar. It was a cross-sectional study conducted with 151 Mtb isolates obtained from the fourth nationwide anti-tuberculosis (TB) drug-resistance survey. Frequency of lineages 1, 2, 3, and 4 were 55, 65, 9, and 22, respectively. The most common sublineage was L1.1.3.1 (n = 31). Respective multi-drug resistant tuberculosis (MDR-TB) frequencies were 1, 1, 0, and 0. Four clusters of 3 (L2), 2 (L4), 2 (L1), and 2 (L2) isolates defined by a 20-single-nucleotide variant (SNV) cutoff were detected. Simpson’s index for sublineages was 0.0709. Such high diversity suggests that the area probably had imported Mtb from many geographical sources. Relatively few genetic clusters and MDR-TB suggest there is a chance the future control will succeed if it is carried out properly.

Funder

Fogarty International Center

National Institute of Allergy and Infectious Diseases, of the National Institutes of Health

Publisher

MDPI AG

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Immunology and Microbiology

Link

https://www.mdpi.com/2414-6366/8/4/239/pdf

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