The Impact of Ramadan Fasting on the Reduction of PASI Score, in Moderate-To-Severe Psoriatic Patients: A Real-Life Multicenter Study

Author:

Damiani Giovanni,Watad Abdulla,Bridgewood Charlie,Pigatto Paolo,Pacifico Alessia,Malagoli Piergiorgio,Bragazzi Nicola,Adawi Mohammad

Abstract

Fasting during the month of Ramadan consists of alternate abstinence and re-feeding periods (circadian or intermittent fasting). Nothing is currently known on the impact of this kind of fasting on psoriasis. A sample of 108 moderate-to-severe plaque psoriasis patients (aged 42.84 ± 13.61 years, 62 males, 46 females) volunteered to take part in the study. A significant change in the “Psoriasis Area and Severity Index” (PASI) score before and after the Ramadan fasting (mean difference = −0.89 ± 1.21, p < 0.0001) was found. At the multivariate regression, the use of apremilast (p = 0.0009), cyclosporine (p = 0.0003), phototherapy (p = 0.0015), interleukin-17 or IL-17 blockers (p < 0.0001), and tumor necrosis factor or TNF blockers (p = 0.0107) predicted the PASI score before the Ramadan fasting. Disease duration (p = 0.0078), use of apremilast (p = 0.0005), and of mammalian target of rapamycin or mTOR inhibitors (p = 0.0034) resulted in independent predictors of the change in the PASI score before and after the Ramadan fasting. The consumption of cyclosporine (p < 0.0001), phototherapy (p = 0.0015), IL-17 blockers (p < 0.0001), mTOR inhibitors (p = 0.0081), and TNF blockers (p = 0.0017) predicted the PASI score after the Ramadan fasting. These findings reflect the influence of dieting strategy, the biological clock, and circadian rhythm on the treatment of plaque psoriasis.

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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