In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2

Author:

Villalobos-Sánchez Erendira1ORCID,García-Ruiz Daniel1,Camacho-Villegas Tanya A.2ORCID,Canales-Aguirre Alejandro A.1ORCID,Gutiérrez-Ortega Abel1ORCID,Muñoz-Medina José E.3ORCID,Elizondo-Quiroga Darwin E.1ORCID

Affiliation:

1. Medical and Pharmaceutical Biotechnology Unit, Center of Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara 44270, Mexico

2. CONACYT, Medical and Pharmaceutical Biotechnology Unit, Center of Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara 44270, Mexico

3. Coordinación de Calidad de Insumos y Laboratorios Especializados, Instituto Mexicano del Seguros Social, México City 27170, Mexico

Abstract

The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (Larrea tridentata) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2.

Funder

CONACYT

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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