Therapeutic Efficiency of Humic Acids in Intoxications

Author:

Vašková Janka1ORCID,Stupák Marek1,Vidová Ugurbaş Martina2,Žatko Daniel3,Vaško Ladislav1

Affiliation:

1. Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia

2. Second Department of Surgery, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia

3. Imuna Pharm, a.s., Šarišské Michaľany, 082 22 Presov, Slovakia

Abstract

Humins, humic and fulvic acids represent molecules with complex structures. These compounds comprising humic substances (HS) exist naturally in soil, brown coal, peat, and water. They are formed during the decomposition and transformation of organic matter (animal and plant remains) and their formation explains several theories. Within their chemical structures, there are numerous phenolic and carboxyl groups and their derivatives that affect their different properties, such as their solubility in water or their absorption of cations or mycotoxins. The manifold chemical structure of HS alters their polyelectrolyte character and thus their chelating efficiency. For many years, HS have been studied due to their detoxification, anti-, and pro-inflammatory or anticancer and antiviral ability. This article summarizes the antioxidant and adsorption properties of humic acids, highlighting their usefulness in intoxications.

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Reference165 articles.

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4. Kononova, M.M. (1966). Soil Organic Matter: Its Nature, Its Role in Soil Formation and in Soil Fertility, Pergamon Press Ltd.

5. Povoledo, D., and Golterman, H.L. (1975). Humic Substances, Their Structure and Function in the Biosphere, Centre Agric. Publ. Doc.

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