Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review
Author:
Sailo Bethsebie Lalduhsaki1, Liu Le2ORCID, Chauhan Suravi1, Girisa Sosmitha1, Hegde Mangala1, Liang Liping3, Alqahtani Mohammed S.4ORCID, Abbas Mohamed5ORCID, Sethi Gautam6, Kunnumakkara Ajaikumar B.1
Affiliation:
1. Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India 2. Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen 518001, China 3. Guangzhou Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China 4. Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia 5. Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia 6. Department of Pharmacology and NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
Abstract
Recent advances in oncological research have highlighted the potential of naturally derived compounds in cancer prevention and treatment. Notably, sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables including broccoli and cabbage, has exhibited potent chemosensitizing capabilities across diverse cancer types of bone, brain, breast, lung, skin, etc. Chemosensitization refers to the enhancement of cancer cell sensitivity to chemotherapy agents, counteracting the chemoresistance often developed by tumor cells. Mechanistically, SFN orchestrates this sensitization by modulating an array of cellular signaling pathways (e.g., Akt/mTOR, NF-κB, Wnt/β-catenin), and regulating the expression and activity of pivotal genes, proteins, and enzymes (e.g., p53, p21, survivin, Bcl-2, caspases). When combined with conventional chemotherapeutic agents, SFN synergistically inhibits cancer cell proliferation, invasion, migration, and metastasis while potentiating drug-induced apoptosis. This positions SFN as a potential adjunct in cancer therapy to augment the efficacy of standard treatments. Ongoing preclinical and clinical investigations aim to further delineate the therapeutic potential of SFN in oncology. This review illuminates the multifaceted role of this phytochemical, emphasizing its potential to enhance the therapeutic efficacy of anti-cancer agents, suggesting its prospective contributions to cancer chemosensitization and management.
Funder
Department of Biotechnology (DBT), Government of India Deanship of Scientific Research at King Khalid University National Natural Science Foundation of China
Subject
Cancer Research,Oncology
Reference145 articles.
1. Cancer causes and treatments;Saini;Int. J. Pharm. Sci. Res.,2020 2. Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives;Khatoon;Semin. Cancer Biol.,2022 3. Ranjan, A., Ramachandran, S., Gupta, N., Kaushik, I., Wright, S., Srivastava, S., Das, H., Srivastava, S., Prasad, S., and Srivastava, S.K. (2019). Role of Phytochemicals in Cancer Prevention. Int. J. Mol. Sci., 20. 4. The hallmarks of cancer;Hanahan;Cell,2000 5. The hallmarks of cancer: The next generation;Hanahan;Cell,2011
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