Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment-Reference-Cited by-同舟云学术

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Published:2023-10-01 Issue:19 Volume:15 Page:4825
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Cammarota Anna Lisa¹,Falco Antonia¹,Basile Anna¹,Molino Carlo²,Chetta Massimiliano³^ORCID,D’Angelo Gianni⁴^ORCID,Marzullo Liberato¹⁵^ORCID,De Marco Margot¹⁵^ORCID,Turco Maria Caterina¹⁵,Rosati Alessandra¹⁵^ORCID

Affiliation:

1. Department of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy

2. General Surgery Unit, A.O.R.N. Cardarelli, 80131 Naples, Italy

3. Medical and Laboratory Genetics Unit, A.O.R.N., Cardarelli, 80131 Naples, Italy

4. Department of Computer Science, University of Salerno, 84084 Fisciano, Italy

5. FIBROSYS s.r.l., University of Salerno, 84081 Baronissi, Italy

Abstract

Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.

Funder

System Innovation for Cancer Early Diagnosis- SICED

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/19/4825/pdf

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