Association of Radiation Dose to the Amygdala–Orbitofrontal Network with Emotion Recognition Task Performance in Patients with Low-Grade and Benign Brain Tumors

Author:

Hardy Sara J.12,Finkelstein Alan34,Milano Michael T.1,Schifitto Giovanni25,Sun Hongying6,Holley Koren5,Usuki Kenneth1,Weber Miriam T.67,Zheng Dandan1ORCID,Seplaki Christopher L.89,Janelsins Michelle16

Affiliation:

1. Department of Radiation Oncology, University of Rochester, Rochester, NY 14620, USA

2. Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA

3. Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA

4. Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center, Rochester, NY 14642, USA

5. Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA

6. Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA

7. Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14642, USA

8. Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA

9. Office for Aging Research and Health Services, University of Rochester Medical Center, Rochester, NY 14642, USA

Abstract

Background: Although data are limited, difficulty in social cognition occurs in up to 83% of patients with brain tumors. It is unknown whether cranial radiation therapy (RT) dose to the amygdala–orbitofrontal network can impact social cognition. Methods: We prospectively enrolled 51 patients with low-grade and benign brain tumors planned for cranial RT. We assessed longitudinal changes on an emotion recognition task (ERT) that measures the ability to recognize emotional states by displaying faces expressing six basic emotions and their association with the RT dose to the amygdala–orbitofrontal network. ERT outcomes included the median time to choose a response (ERTOMDRT) or correct response (ERTOMDCRT) and total correct responses (ERTHH). Results: The RT dose to the amygdala–orbitofrontal network was significantly associated with longer median response times on the ERT. Increases in median response times occurred at lower doses than decreases in total correct responses. The medial orbitofrontal cortex was the most important variable on regression trees predicting change in the ERTOMDCRT. Discussion: This is, to our knowledge, the first study to show that off-target RT dose to the amygdala–orbitofrontal network is associated with performance on a social cognition task, a facet of cognition that has previously not been mechanistically studied after cranial RT.

Funder

Department of Radiation Oncology

Schmitt Foundation

DP2

Wilmot Cancer Research Fellowship and Cancer Control T32

University of Rochester CTSA

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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