Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers

Author:

Soror Tamer12,Paul Justina3,Melchert Corinna1,Idel Christian3,Rades Dirk1,Bruchhage Karl-Ludwig3,Kovács György4ORCID,Leichtle Anke3ORCID

Affiliation:

1. Radiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, Germany

2. National Cancer Institute (NCI), Radiation Oncology Department, Cairo University, Giza 12613, Egypt

3. Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, Germany

4. Università Cattolica del Sacro Cuore, Gemelli-INTERACTS, 00168 Rome, Italy

Abstract

(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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