The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer-Reference-Cited by-同舟云学术

The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer

Published:2023-11-16 Issue:22 Volume:15 Page:5435
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Maghsoudi Hossein¹²^ORCID,Sheikhnia Farhad¹²^ORCID,Sitarek Przemysław³^ORCID,Hajmalek Nooshin⁴,Hassani Sepideh²^ORCID,Rashidi Vahid¹,Khodagholi Sadaf⁵,Mir Seyed Mostafa⁶,Malekinejad Faezeh¹²,Kheradmand Fatemeh²⁷⁸,Ghorbanpour Mansour⁹^ORCID,Ghasemzadeh Navid²,Kowalczyk Tomasz¹⁰^ORCID

Affiliation:

1. Student Research Committee, Urmia University of Medical Sciences, Urmia 57147-83734, Iran

2. Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia 57147-83734, Iran

3. Department of Medical Biology, Medical University of Lodz, 90-151 Lodz, Poland

4. Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol 47176-47754, Iran

5. School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada

6. Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 49189-36316, Iran

7. Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia 57147-83734, Iran

8. Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia 57147-83734, Iran

9. Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-88349, Iran

10. Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland

Abstract

Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat diet, is considered to be the main cause of PC. Inflammatory cells are believed to play a crucial role in tumor progression. Therefore, nonsteroidal anti-inflammatory drugs along with their effects on the treatment of inflammation-related diseases, can prevent cancer and its progression by suppressing various inflammatory pathways. Recent evidence shows that nonsteroidal anti-inflammatory drugs are effective in the prevention and treatment of prostate cancer. In this review, we discuss the different pathways through which these drugs exert their potential preventive and therapeutic effects on prostate cancer.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/22/5435/pdf

Reference166 articles.

1. Cancer statistics;Siegel;2020 CA Cancer J. Clin. Am. Cancer Soc.,2020

2. Virtanen, V., Paunu, K., Ahlskog, J.K., Varnai, R., Sipeky, C., and Sundvall, M. (2019). PARP inhibitors in prostate cancer–the preclinical rationale and current clinical development. Genes, 10.

3. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA A Cancer J. Clin.,2021

4. Giri, V.N., and Beebe-Dimmer, J.L. (2016). Familial Prostate Cancer. Seminars in Oncology, Elsevier.

5. Retropubic, laparoscopic, and robot-assisted radical prostatectomy: Surgical, oncological, and functional outcomes: A systematic review;Celestino;Urol. Int.,2014