Clinical Theranostics in Recurrent Gliomas: A Review

Author:

Hoggarth Austin R.123,Muthukumar Sankar2ORCID,Thomas Steven M.2ORCID,Crowley James4,Kiser Jackson4ORCID,Witcher Mark R.123

Affiliation:

1. Department of Neurosurgery, Carilion Clinic, 1906 Belleview Avenue, Roanoke, VA 24014, USA

2. Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA 24016, USA

3. School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA

4. Carilion Clinic Radiology, Roanoke, VA 24016, USA

Abstract

Gliomas represent the most commonly occurring tumors in the central nervous system and account for approximately 80% of all malignant primary brain tumors. With a high malignancy and recurrence risk, the prognosis of high-grade gliomas is poor, with a mean survival time of 12–18 months. While contrast-enhanced MRI serves as the standard diagnostic imaging modality for gliomas, it faces limitations in the evaluation of recurrent gliomas, failing to distinguish between treatment-related changes and tumor progression, and offers no direct therapeutic options. Recent advances in imaging modalities have attempted to address some of these limitations, including positron emission tomography (PET), which has demonstrated success in delineating tumor margins and guiding the treatment of recurrent gliomas. Additionally, with the advent of theranostics in nuclear medicine, PET tracers, when combined with therapeutic agents, have also evolved beyond a purely diagnostic modality, serving both diagnostic and therapeutic roles. This review will discuss the growing involvement of theranostics in diagnosing and treating recurrent gliomas and address the associated impact on quality of life and functional recovery.

Publisher

MDPI AG

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Proteomics Studies on Extracellular Vesicles Derived from Glioblastoma: Where Do We Stand?;International Journal of Molecular Sciences;2024-09-10

2. Nuclear Medicine Imaging Techniques in Glioblastomas;Neurochemical Research;2024-09-05

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