Confocal Laser Endomicroscopy for Detection of Early Upper Gastrointestinal Cancer

Author:

Han Wei1,Kong Rui1,Wang Nan1,Bao Wen1,Mao Xinli2,Lu Jie3

Affiliation:

1. Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China

2. Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Zhejiang 317099, China

3. Department of Gastroenterology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China

Abstract

Esophageal and gastric cancers are common diseases with high morbidity and mortality; thus, early detection and treatment are beneficial to improve prognosis. Confocal laser endomicroscopy (CLE) is a novel imaging technique that permits the histological analysis of tissues during endoscopy. CLE has been shown to uniquely affect the diagnosis of early upper gastrointestinal cancers. Relevant literature was searched using PubMed and Google Scholar databases. Despite inherent flaws, CLE can reduce tissue damage and improve diagnostic accuracy to a certain extent. CLE in combination with other imaging methods can help enhance the detection rate and avoid unnecessary biopsies in the management of esophageal or gastric cancer and precancerous lesions. CLE is of great significance in the diagnosis and surveillance of early cancers of the upper gastrointestinal tract. Further technical innovations and the standardisation of CLE will make it more responsive to the needs of routine clinical applications.

Funder

Shanghai Pudong New Area Science and Technology Commission

Shanghai “Rising Stars of Medical Talent” Youth Development Program—Outstanding Youth Medical Talents

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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