Comments on and Illustrations of the EFSUMB CEUS Guidelines: Transabdominal and Endoscopic Ultrasound Features of Intrapancreatic Metastases and the Role of Multiparametric Imaging and EUS-Guided Sampling in Rare Pancreatic Tumors

Author:

Möller Kathleen1,Jenssen Christian23ORCID,Braden Barbara4,Hocke Michael5,Yamashita Yasunobu6ORCID,Arcidiacono Paolo Giorgio7ORCID,Ignee André8ORCID,D’Onofrio Mirko9ORCID,Fusaroli Pietro10ORCID,Bhutani Manoop S.11,Dong Yi12ORCID,Sun Siyu13,Faiss Siegbert1,Dietrich Christoph F.14ORCID

Affiliation:

1. Medical Department I/Gastroenterology, Sana Hospital Lichtenberg, 10365 Berlin, Germany

2. Department of Internal Medicine, Krankenhaus Märkisch-Oderland, 15344 Strausberg, Germany

3. Brandenburg Institute for Clinical Ultrasound (BICUS), Medical University Brandenburg, 16816 Neuruppin, Germany

4. Translational Gastroenterology Unit, Oxford University Hospitals, OX3 9DU Oxford, UK

5. Medical Department, Helios Klinikum Meiningen, 98617 Meiningen, Germany

6. Second Department of Internal Medicine, Wakayama Medical University, Wakayama City 641-8509, Japan

7. Division of Pancreatobiliary Endoscopy and Endosonography, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, 20132 Milan, Italy

8. Medical Clinic—Department for Gastroenterology and Rheumatology, Klinikum Wuerzburg Mitte, 97070 Wuerzburg, Germany

9. Department of Radiology, GB Rossi University Hospital, University of Verona, 37129 Verona, Italy

10. Department of Medical and Surgical Sciences, Gastrointestinal Unit, University of Bologna/Hospital of Imola, 40126 Bologna, Italy

11. Department of Gastroenterology Hepatology and Nutrition, UTMD Anderson Cancer Center, Houston, TX 77030-4009, USA

12. Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

13. Department of Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang 110022, China

14. Department Allgemeine Innere Medizin der Kliniken (DAIM) Hirslanden Beau Site, Salem und Permanence, 3013 Bern, Switzerland

Abstract

A definite pathologic diagnosis of intrapancreatic metastasis is crucial for the management decision, i.e., curative or palliative surgery versus chemotherapy or conservative/palliative therapy. This review focuses on the appearance of intrapancreatic metastases on native and contrast-enhanced transabdominal ultrasound and endoscopic ultrasound. Differences and similarities in relation to the primary tumor, and the differential diagnosis from pancreatic carcinoma and neuroendocrine neoplasms are described. The frequency of intrapancreatic metastases in autopsy studies and surgical resection studies will be discussed. Further emphasis is placed on endoscopic ultrasound-guided sampling to confirm the diagnosis.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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