Salvage Surgery for Small-Cell Lung Cancer—A Literature Review

Author:

Motas Natalia123ORCID,Manolache Veronica13,Scarci Marco4ORCID,Nimigean Victor5,Nimigean Vanda Roxana6,Simion Laurentiu78,Mizea Madalina Cristiana12,Trifanescu Oana Gabriela910ORCID,Galateanu Bianca11ORCID,Gherghe Mirela12ORCID,Capsa Cristina Mirela13,Gonzalez-Rivas Diego314,Davidescu Mihnea Dan12

Affiliation:

1. Discipline of Thoracic Surgery, “Carol Davila” University of Medicine and Pharmacy, 022328 Bucharest, Romania

2. Department of Thoracic Surgery, “Prof. Dr. Al. Trestioreanu” Institute of Oncology, 022328 Bucharest, Romania

3. Department of Thoracic Surgery, Oncology Hospital Memorial, 013812 Bucharest, Romania

4. Department of Thoracic Surgery, Imperial College NHS Healthcare, Hammersmith Hospital Du Cane Road, London W12 0HS, UK

5. Department of Anatomy, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy in Bucharest, 022328 Bucharest, Romania

6. Department of Oral Rehabilitation, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy in Bucharest, 022328 Bucharest, Romania

7. Discipline of General and Oncological Surgery, “Carol Davila” University of Medicine and Pharmacy, 022328 Bucharest, Romania

8. Department of General and Oncologic Surgery, “Prof. Dr. Al. Trestioreanu” Institute of Oncology, 022328 Bucharest, Romania

9. Discipline of Oncology, “Carol Davila” University of Medicine and Pharmacy, 022328 Bucharest, Romania

10. Department of Radiotherapy, “Prof. Dr. Al. Trestioreanu” Institute of Oncology, 022328 Bucharest, Romania

11. Department of Biochemistry and Molecular Biology, University of Bucharest, 022328 Bucharest, Romania

12. Discipline of Nuclear Medicine, “Prof. Dr. Al. Trestioreanu” Institute of Oncology and University Emergency Military Hospital “Dr. Carol Davila”, 022328 Bucharest, Romania

13. Department of Radiology “Prof. Dr. Alexandru Trestioreanu”, 022328 Bucharest, Romania

14. Department of Thoracic Surgery and Minimally Invasive Thoracic Surgery Unit (UCTMI), Coruña University Hospital, 15008 Coruña, Spain

Abstract

(1) Background: Salvation surgery for small-cell lung cancer (SCLC) is exceptionally performed, and only a few cases are published. (2) Methods: There are 6 publications that present 17 cases of salvation surgery for SCLC—the salvation surgery was performed in the context of modern clearly established protocols for SCLC and after including SCLC in the TNM (tumor, node, metastasis) staging in 2010. (3) Results: After a median follow-up of 29 months, the estimated overall survival (OS) was 86 months. The median estimated 2-year survival was 92%, and the median estimated 5-year survival was 66%. (4) Conclusion: Salvage surgery for SCLC is a relatively new and extremely uncommon concept and represents an alternative to second-line chemotherapy. It is valuable because it may offer a reasonable treatment for selected patients, good local control, and a favorable survival outcome.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Reference41 articles.

1. LoCicero, J., Feins, R.H., Colson, Y.L., and Rocco, G. (2019). Shields’ General Thoracic Surgery, Wolters Kluwer. [8th ed.].

2. (2023, March 06). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Small Cell Lung Cancer. Version 2.2022—24 November 2021. Available online: https://www.nccn.org/professionals/physician_gls/pdf/sclc.pdf.

3. The IASLC Lung Cancer Staging Project Proposals Regarding the Relevance of TNM in the Pathologic Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the TNM Classification for Lung Cancer;Vallieres;J. Thor. Oncol.,2009

4. Surgical resection in the management of small cell carcinoma of the lung;Shields;J. Thorac. Cardiovasc. Surg.,1982

5. Surgery for small-cell lung cancer;Anraku;Semin. Thorac. Cardiovasc. Surg.,2006

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