Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification

Author:

Talapatra Jyotirmayee12ORCID,Reddy Mamatha M.12ORCID

Affiliation:

1. The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Bhubaneswar 751024, India

2. School of Biotechnology, KIIT Deemed to Be University, Bhubaneswar 751024, India

Abstract

Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for unrestricted cell proliferation, and some of the lipids act as signaling pathway mediators. In this review, we focus on the role of lipid metabolism in embryonal neoplasms with MYCN dysregulation. We specifically review lipid metabolic reactions in neuroblastoma, retinoblastoma, medulloblastoma, Wilms tumor, and rhabdomyosarcoma and the possibility of targeting lipid metabolism. Additionally, the regulation of lipid metabolism by the MYCN oncogene is discussed.

Funder

Department of Biotechnology

Indian Council of Medical Research

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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