Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer-Reference-Cited by-全球学者库

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Published:2023-04-07 Issue:8 Volume:15 Page:2195
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Alizadeh Javad¹^ORCID,Kavoosi Mahboubeh¹,Singh Navjit¹^ORCID,Lorzadeh Shahrokh¹,Ravandi Amir²,Kidane Biniam³⁴^ORCID,Ahmed Naseer⁴⁵,Mraiche Fatima⁶⁷^ORCID,Mowat Michael R.⁴⁸^ORCID,Ghavami Saeid¹⁹¹⁰¹¹^ORCID

Affiliation:

1. Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada

2. Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada

3. Section of Thoracic Surgery, Department of Surgery, Health Sciences Centre, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 6C5, Canada

4. CancerCare Manitoba Research Institute, Winnipeg, MB R3E 0V9, Canada

5. Department of Radiology, Section of Radiation Oncology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada

6. College of Pharmacy, QU Health, Qatar University, Doha 2713, Qatar

7. Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada

8. Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada

9. Research Institute of Oncology and Hematology, Winnipeg, MB R3E 0V9, Canada

10. Faculty of Medicine in Zabrze, Academia of Silesia, 41-800 Zabrze, Poland

11. Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 3P5, Canada

Abstract

Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.

Funder

CancerCare Manitoba Foundation

Vanier CIHR Ph.D. studentship

the Max Rady College of Medicine’s BSc (Med) program

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/8/2195/pdf

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