Diffusion-Weighted MRI for Treatment Response Assessment in Osteoblastic Metastases—A Repeatability Study

Author:

Eveslage Maria1ORCID,Rassek Philipp2,Riegel Arne3,Maksoud Ziad3ORCID,Bauer Jochen3ORCID,Görlich Dennis1ORCID,Noto Benjamin123ORCID

Affiliation:

1. Institute of Biostatistics and Clinical Research, University of Münster, 48149 Münster, Germany

2. Department of Nuclear Medicine, University Hospital Münster, 48149 Münster, Germany

3. Clinic for Radiology, University Hospital Münster, 48149 Münster, Germany

Abstract

The apparent diffusion coefficient (ADC) is a candidate marker of treatment response in osteoblastic metastases that are not evaluable by morphologic imaging. However, it is unclear whether the ADC meets the basic requirement for reliable treatment response evaluation, namely a low variance of repeated measurements in relation to the differences found between viable and nonviable metastases. The present study addresses this question by analyzing repeated in vivo ADCmedian measurements of 65 osteoblastic metastases in nine patients, as well as phantom measurements. PSMA-PET served as a surrogate for bone metastasis viability. Measures quantifying repeatability were calculated and differences in mean ADC values according to PSMA-PET status were examined. The relative repeatability coefficient %RC of ADCmedian measurements was 5.8% and 12.9% for phantom and in vivo measurements, respectively. ADCmedian values of bone metastases ranged from 595×10−6mm2/s to 2090×10−6mm2/s with an average of 63% higher values in nonviable metastases compared with viable metastases (p < 0.001). ADC shows a small repeatability coefficient in relation to the difference in ADC values between viable and nonviable metastases. Therefore, ADC measurements fulfill the technical prerequisite for reliable treatment response evaluation in osteoblastic metastases.

Funder

Medical Faculty, University of Münster, Germany

Open-Access Publication Fund of the University of Münster

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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