Deep Learning Prediction Model for Patient Survival Outcomes in Palliative Care Using Actigraphy Data and Clinical Information

Author:

Huang Yaoru12ORCID,Roy Nidita3ORCID,Dhar Eshita45,Upadhyay Umashankar456ORCID,Kabir Muhammad Ashad7ORCID,Uddin Mohy8,Tseng Ching-Li29ORCID,Syed-Abdul Shabbir4510ORCID

Affiliation:

1. Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan

2. Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan

3. Department of Computer Science and Engineering, Chittagong University of Engineering and Technology, Chittagong 4349, Bangladesh

4. Graduate Institute of Biomedical Informatics, College of Medical Sciences and Technology, Taipei Medical University, Taipei 106, Taiwan

5. International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei 106, Taiwan

6. Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India

7. School of Computing, Mathematics and Engineering, Charles Sturt University, Bathurst, NSW 2678, Australia

8. Research Quality Management Section, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard—Health Affairs, Riyadh 11481, Saudi Arabia

9. International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan

10. School of Gerontology and Long-Term Care, College of Nursing, Taipei Medical University, Taipei 110, Taiwan

Abstract

(1) Background: Predicting the survival of patients in end-of-life care is crucial, and evaluating their performance status is a key factor in determining their likelihood of survival. However, the current traditional methods for predicting survival are limited due to their subjective nature. Wearable technology that provides continuous patient monitoring is a more favorable approach for predicting survival outcomes among palliative care patients. (2) Aims and objectives: In this study, we aimed to explore the potential of using deep learning (DL) model approaches to predict the survival outcomes of end-stage cancer patients. Furthermore, we also aimed to compare the accuracy of our proposed activity monitoring and survival prediction model with traditional prognostic tools, such as the Karnofsky Performance Scale (KPS) and the Palliative Performance Index (PPI). (3) Method: This study recruited 78 patients from the Taipei Medical University Hospital’s palliative care unit, with 66 (39 male and 27 female) patients eventually being included in our DL model for predicting their survival outcomes. (4) Results: The KPS and PPI demonstrated an overall accuracy of 0.833 and 0.615, respectively. In comparison, the actigraphy data exhibited a higher accuracy at 0.893, while the accuracy of the wearable data combined with clinical information was even better, at 0.924. (5) Conclusion: Our study highlights the significance of incorporating clinical data alongside wearable sensors to predict prognosis. Our findings suggest that 48 h of data is sufficient for accurate predictions. The integration of wearable technology and the prediction model in palliative care has the potential to improve decision making for healthcare providers and can provide better support for patients and their families. The outcomes of this study can possibly contribute to the development of personalized and patient-centered end-of-life care plans in clinical practice.

Funder

Taipei Medical University and Taipei Medical University Hospital

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Reference50 articles.

1. Palliative care: The World Health Organization’s global perspective;Marlin;J. Pain Symptom Manag.,2002

2. World Health Organization (2023, February 06). Palliative Care. Available online: https://www.who.int/news-room/fact-sheets/detail/palliative-care.

3. National Hospice and Palliative Care Organization (2023, February 06). Hospice Facts & Figures. Available online: https://www.nhpco.org/hospice-facts-figures/.

4. Patel, S.D., Davies, A., Laing, E., Wu, H., Mendis, J., and Dijk, D.-J. (2023). Prognostication in Advanced Cancer by Combining Actigraphy-Derived Rest-Activity and Sleep Parameters with Routine Clinical Data: An Exploratory Machine Learning Study. Cancers, 15.

5. White, N., Reid, F., Harris, A., Harries, P., and Stone, P. (2016). A systematic review of predictions of survival in palliative care: How accurate are clinicians and who are the experts?. PLoS ONE, 11.

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