Management of Metastatic Pancreatic Cancer—Comparison of Global Guidelines over the Last 5 Years-Reference-Cited by-同舟云学术

Management of Metastatic Pancreatic Cancer—Comparison of Global Guidelines over the Last 5 Years

Published:2023-09-02 Issue:17 Volume:15 Page:4400
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Pajewska Monika¹²^ORCID,Partyka Olga¹²,Czerw Aleksandra¹²^ORCID,Deptała Andrzej³^ORCID,Cipora Elżbieta⁴^ORCID,Gąska Izabela⁴,Wojtaszek Marek⁴,Sygit Katarzyna⁵^ORCID,Sygit Marian⁵,Krzych-Fałta Edyta⁶,Schneider-Matyka Daria⁷,Cybulska Anna M.⁷^ORCID,Grochans Elżbieta⁷^ORCID,Asendrych-Woźniak Alicja⁸,Romanowicz Agnieszka⁸,Drobnik Jarosław⁹^ORCID,Bandurska Ewa¹⁰,Ciećko Weronika¹⁰^ORCID,Maciuszek-Bartkowska Barbara¹¹,Curyło Mateusz¹²¹³,Wróbel Kacper¹⁴^ORCID,Kozłowski Remigiusz¹⁵^ORCID,Marczak Michał¹⁶

Affiliation:

1. Department of Health Economics and Medical Law, Medical University of Warsaw, 01-445 Warsaw, Poland

2. Department of Economic and System Analyses, National Institute of Public Health NIH-National Research Institute, 00-791 Warsaw, Poland

3. Department of Oncology Propaedeutics, Medical University of Warsaw, 01-445 Warsaw, Poland

4. Medical Institute, Jan Grodek State University in Sanok, 38-500 Sanok, Poland

5. Faculty of Health Sciences, Calisia University, 62-800 Kalisz, Poland

6. Department of Basic of Nursing, Faculty of Health Sciences, Medical University of Warsaw, 01-445 Warsaw, Poland

7. Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland

8. Clinical Department of Oncology, The National Institute of Medicine of the Ministry of Interior and Administration, 02-507 Warsaw, Poland

9. Department of Family Medicine, Faculty of Medicine, Wroclaw Medical University, 51-141 Wroclaw, Poland

10. Center for Competence Development, Integrated Care and e-Health, Medical University of Gdansk, 80-204 Gdansk, Poland

11. Department of Biophysics, Poznan University of Medical Sciencies, 60-780 Poznan, Poland

12. Department of Internal Medicine, Rehabilitation and Physical Medicine, Medical University of Lodz, 90-647 Lodz, Poland

13. Medical Rehabilitation Department, The Ministry of the Interior and Administration Hospital, 30-053 Cracow, Poland

14. Department of Management and Logistics in Healthcare, Medical University of Lodz, 90-131 Lodz, Poland

15. Center for Security Technologies in Logistics, Faculty of Management, University of Lodz, 90-237 Lodz, Poland

16. Collegium of Management, WSB Merito University in Warsaw, 03-204 Warszawa, Poland

Abstract

Pancreatic cancer (PC) is usually diagnosed at an advanced stage of its development, which results in lower overall survival (OS). Prognosis is also poor even with curative-intent surgery. Approximately 80% of patients with localized PDAC have micrometastases at the time of diagnosis, which leads to a worse prognosis than in other cancers. The objective of this study is to present the progress in the treatment of metastatic pancreatic cancer based on the recommendations of oncological scientific societies, such as ESMO, NCCN, ASCO, NICE and SEOM, over the last 5 years. Combined FOLFIRINOX therapy is mostly a recommended therapy among patients with good performance statuses, while gemcitabine is recommended for more fragile patients as a first-line treatment. The newest guidelines suggest that molecular profiling of the tumor should be the first step in determining the course of treatment. The use of modern molecular therapies in patients with specific gene mutations should extend the survival of patients with this disease.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/17/4400/pdf

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