The Emerging Role of Histone Deacetylase Inhibitors in Cervical Cancer Therapy-Reference-Cited by-同舟云学术

The Emerging Role of Histone Deacetylase Inhibitors in Cervical Cancer Therapy

Published:2023-04-10 Issue:8 Volume:15 Page:2222
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Psilopatis Iason¹^ORCID,Garmpis Nikolaos²³^ORCID,Garmpi Anna⁴,Vrettou Kleio⁵,Sarantis Panagiotis⁶^ORCID,Koustas Evangelos⁶,Antoniou Efstathios A.²³,Dimitroulis Dimitrios²³,Kouraklis Gregory⁷,Karamouzis Michail V.⁶^ORCID,Marinos Georgios⁸,Kontzoglou Konstantinos²³,Nonni Afroditi⁹,Nikolettos Konstantinos¹⁰,Fleckenstein Florian N.¹¹¹²^ORCID,Zoumpouli Christina¹³,Damaskos Christos²¹⁴^ORCID

Affiliation:

1. Department of Gynecology, Charité—Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

2. Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

3. Nikolaos Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

4. First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

5. Department of Cytopathology, Sismanogleio General Hospital, 15126 Athens, Greece

6. Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

7. Department of Surgery, Evgenideio Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

8. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

9. First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

10. Obstetric and Gynecologic Clinic, Medical School, Democritus University of Thrace, 68110 Alexandroupolis, Greece

11. Department of Diagnostic and Interventional Radiology, Charité—Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

12. Berlin Institute of Health, Charité—Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, 13353 Berlin, Germany

13. Department of Pathology, Sismanogleio General Hospital, 15126 Athens, Greece

14. Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece

Abstract

Cervical carcinoma is one of the most common cancers among women globally. Histone deacetylase inhibitors (HDACIs) constitute anticancer drugs that, by increasing the histone acetylation level in various cell types, induce differentiation, cell cycle arrest, and apoptosis. The aim of the current review is to study the role of HDACIs in the treatment of cervical cancer. A literature review was conducted using the MEDLINE and LIVIVO databases with a view to identifying relevant studies. By employing the search terms “histone deacetylase” and “cervical cancer”, we managed to identify 95 studies published between 2001 and 2023. The present work embodies the most up-to-date, comprehensive review of the literature centering on the particular role of HDACIs as treatment agents for cervical cancer. Both well-established and novel HDACIs seem to represent modern, efficacious anticancer drugs, which, alone or in combination with other treatments, may successfully inhibit cervical cancer cell growth, induce cell cycle arrest, and provoke apoptosis. In summary, histone deacetylases seem to represent promising future treatment targets in cervical cancer.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/8/2222/pdf

Reference141 articles.

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4. American Cancer Society (2020). Signs and Symptoms of Cervical Cancer, American Cancer Society.

5. American Cancer Society (2021). Treatment Options for Cervical Cancer, by Stage, American Cancer Society.

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