From Oncogenesis to Theranostics: The Transformative Role of PSMA in Prostate Cancer-Reference-Cited by-同舟云学术

From Oncogenesis to Theranostics: The Transformative Role of PSMA in Prostate Cancer

Published:2024-08-31 Issue:17 Volume:16 Page:3039
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Hameed Muhammad Y.¹,Gul Maryam²,Chaudhry Abbas²,Muzaffar Huma²,Sheikh Mubashir²,Chee Winson¹^ORCID,Ayyash Sondos³,Ayyash Jenna⁴,Al-Hindi Mohannad¹,Shahare Humam¹,Chaudhry Ammar⁵

Affiliation:

1. College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72223, USA

2. Crescent Theranostics, Anaheim, CA 982902, USA

3. Department of Medical Oncology, University Health Network (UHN), Toronto, ON M5G 2C1, Canada

4. Department of Biology, University of Toronto, Toronto, ON M5S 1A1, Canada

5. Astrazeneca, Gaithersburg, MD 20878, USA

Abstract

Prostate cancer, a leading cause of cancer-related mortality among men, is characterized by complex genetic and epigenetic alterations, dysregulation of oncogenic pathways, and a dynamic tumor microenvironment. Advances in molecular diagnostics and targeted therapies have significantly transformed the management of this disease. Prostate-specific membrane antigen (PSMA) has emerged as a critical biomarker, enhancing the precision of prostate cancer diagnosis and treatment. Theranostics, which integrates PSMA-targeted imaging with radioligand therapies, has shown remarkable efficacy in detecting and treating advanced prostate cancer. By leveraging the dual capabilities of PSMA-based diagnostics and therapeutic agents, theranostics offers a personalized approach that improves patient outcomes. This comprehensive review explores the latest developments in PSMA-targeted theranostics and their impact on the future of prostate cancer management, highlighting key clinical trials and emerging therapeutic strategies.

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/17/3039/pdf

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