Redox Regulation of PTEN by Reactive Oxygen Species: Its Role in Physiological Processes
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Published:2024-02-04
Issue:2
Volume:13
Page:199
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ISSN:2076-3921
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Container-title:Antioxidants
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language:en
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Short-container-title:Antioxidants
Author:
Trinh Vu Hoang12, Nguyen Huu Thang1, Sah Dhiraj Kumar1ORCID, Choi Jin Myung1, Yoon Hyun Joong1ORCID, Park Sang Chul3, Jung Yu Seok4, Lee Seung-Rock1
Affiliation:
1. Department of Biochemistry, Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501190, Republic of Korea 2. Department of Oncology, Department of Medical Sciences, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam 3. The Future Life & Society Research Center, Advanced Institute of Aging Science, Chonnam National University, Gwangju 61469, Republic of Korea 4. Chonnam National University Medical School, Gwangju 501190, Republic of Korea
Abstract
Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In addition, PTEN plays an essential role in other physiological events associated with cell growth demands, such as ischemia-reperfusion, nerve injury, and immune responsiveness. Therefore, recently, PTEN inhibition has emerged as a potential therapeutic intervention in these situations. Increasing evidence demonstrates that reactive oxygen species (ROS), especially hydrogen peroxide (H2O2), are produced and required for the signaling in many important cellular processes under such physiological conditions. ROS have been shown to oxidize PTEN at the cysteine residue of its active site, consequently inhibiting its function. Herein, we provide an overview of studies that highlight the role of the oxidative inhibition of PTEN in physiological processes.
Funder
Basic Research Program National Research Foundation of Korea Ministry of Science, ICT, and Technology KBRI Basic Research Program Korea Brain Research Institute
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
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