Author:
Ognjanović BI,Marković SD,Pavlović SZ,Žikić RV,Štajn AŠ,Saičić ZS
Abstract
The effects of selenium (Se) on antioxidant defense system in
liver and kidneys of rats with cadmium (Cd)-induced toxicity were
examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl2 for 4
weeks) resulted in increased lipid peroxidation (LP) in both
organs (p<0.005 and p<0.01). Vitamin C (Vit C) was decreased
in the liver (p<0.005), whereas vitamin E (Vit E) was increased in
the liver and kidneys (p<0.005 and p<0.05) of Cd-exposed
animals. Superoxide dismutase (SOD) and glutathione peroxidase
(GSH-Px) activities were decreased in both tissues (p<0.05 and
p<0.005), whereas catalase (CAT) activity was decreased only in
liver (p<0.005). Glutathione S-transferase (GST) increased in
both tissues (p<0.005 and p<0.01). Treatment with Se (0.5 mg
Se/kg b.m./day as Na2SeO3 for 4 weeks) significantly increased
liver and kidneys SOD and GSH-Px activities (p<0.05 to
p<0.005), as well as CAT and GST activities only in the liver
(p<0.01). In animals exposed to Se, both the concentrations of
Vit C (p<0.01) and Vit E (p<0.005) were increased in both
tissues. Co-treatment with Se resulted in reversal of oxidative
stress with significant decline in analyzed tissues Cd burden. Our
results show that Se may ameliorate Cd-induced oxidative stress
by decreasing LP and altering antioxidant defense system in rat
liver and kidneys and that Se demonstrates the protective effect
from cadmium-induced oxidative damage.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
182 articles.
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