Affiliation:
1. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Abstract
Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized – however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Reference33 articles.
1. 1. Information NC for B, Pike USNL of M 8600 R, MD B, Usa 20894. Contraception: Hormonal contraceptives [Internet]. Inf. Internet. Institute for Quality and Efficiency in Health Care (IQWiG); 2017 [cited 2022 Apr 4]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441576/
2. 2. Pletzer BA, Kerschbaum HH. 50 years of hormonal contraception-time to find out, what it does to our brain. Front Neurosci 2014;8:256. https://doi.org/10.3389/fnins.2014.00256
3. 3. United Nations. Contraceptive Use by Method 2019: Data Booklet [Internet]. UN; 2019 [cited 2021 Oct 19]. Available from: https://www.un-ilibrary.org/content/books/9789210046527
4. 4. Williams NM, Randolph M, Rajabi-Estarabadi A, Keri J, Tosti A. Hormonal contraceptives and dermatology. Am J Clin Dermatol 2021;22:69-80. https://doi.org/10.1007/s40257-020-00557-5
5. 5. Chen JT, Kotani K. Oral contraceptive therapy increases oxidative stress in pre-menopausal women. Int J Prev Med 2012;3:893-896. https://doi.org/10.4103/2008-7802.104862
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献