Immunocytochemical Demonstration of M1 Muscarinic Acetylcholine Receptors at the Presynaptic and Postsynaptic Membranes of Rat Diaphragm Endplates-Reference-Cited by-同舟云学术

Immunocytochemical Demonstration of M1 Muscarinic Acetylcholine Receptors at the Presynaptic and Postsynaptic Membranes of Rat Diaphragm Endplates

Published:2011-02-14 Issue: Volume: Page:185-188
ISSN:1802-9973
Container-title:Physiological Research
language:en
Short-container-title:Physiol Res

Author:

MALOMOUZH A. I.¹,ARKHIPOVA S. S.,NIKOLSKY E. E.,VYSKOČIL F.²

Affiliation:

1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia

2. Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Abstract

M1-muscarinic acetylcholine (ACh) receptors (M1R) were directly demonstrated immunocytochemically in electronmicroscopic images of rat diaphragm neuromuscular junctions (NMJ). Specific electron-dense granules were located at presynaptic nerve ending membranes and in the sarcolemma in the depths of postsynaptic folds. This first visualization of M1R on both sides of the NMJ is in agreement with previous pharmacological data on the regulatory role of M1R in quantal and non-quantal ACh release.

Publisher

Institute of Physiology of the Czech Academy of Sciences

Subject

General Medicine,Physiology

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