Abstract
A large body of evidence has implicated reactive carbonyl
compounds as glycotoxic mediators of carbonyl stress. This
review is focused on the pathophysiological effects of
α-oxoaldehydes in diabetes and related complications,
summarizing the state-of-the-art on the endogenously produced
carbonyls methylglyoxal, glyoxal and 3-deoxyglucosone, formed
as glycolytic intermediates during metabolic conversion of
glucose, via Maillard reaction by degradation of glycated proteins,
and during lipid peroxidation process. Their role in the advanced
glycation process and detrimental effects on vascular tissue are
discussed.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
120 articles.
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