Author:
Mina J. Jabbar ,Wedad K. Ali
Abstract
In recent years, gels have been preferentially used for cosmetics and topical pharmaceutical preparations due to their favorable characteristics, such as being greaseless, readily spreadable and easily removable. However, one
obstacle that faced it was the inability to enclose hydrophobic compounds. Therefore, a novel approach was developed to circumvent this limitation by mixing the gel with an emulsion, which led to creation of a new topical drug delivery system known as emulgel. Emulgel preserves all favorable features of gel and provides also dual release for drug, thus can be utilized effectively in controlling release and absorption of medication after topical application. Emulgel preparation requires coherent steps, this includes preparation of emulsion and gel and determining their mixing ratio. Finally, the prepared emulgels should be evaluated to ensure their suitability and efficacy for the topical application.
Publisher
Al Mustansiriyah University - College of Pharmacy
Reference50 articles.
1. - Mohammed, M. M.; Hamadi, S. A.; Aljaf, A. N. Formulation of melatonin as a cream and studying the release, diffusion, and stability of the cream. Al Mustansiriyah Journal of Pharmac-eutical Sciences 2009. 6 (1): 43-55.
2. - Buhse, L.; Kolinski, R.; Westenberger, B.; Wokovich, A.; Spencer, J.; Chen, C. W.; Turujman, S.; Gautam-Basak, M.; Kang, G. J.; Kibbe, A. Topical drug classification. International journal of pharmaceutics 2005. 295 (1-2): 101-112.
3. - Dhawas, V.; Dhabarde, D.; Patil, S. Emulgel: A comprehensive review for novel topical drug delivery system. International Journal of Recent Scientific Research 2020. 11 (4):38134-38138.
4. - Kumar, D.; Rajni, R. S.; Rani, S.; Kumari, R. Formulation And Evaluation Of Emulgel Of An Antifungal Drug For Topical Drug Delivery. Journal of Pharmaceutical Negative Results 2023: 4087-4100.
5. - Iqbal, M. A.; Md, S.; Sahni, J. K.; Baboota, S.; Dang, S.; Ali, J. Nanostructured lipid carriers system: recent advances in drug delivery. Journal of drug targeting 2012. 20 (10): 813-830.