Predictive and Prognostic Significance of the State of Gene TOP2A as a Marker of Anthracyclines Sensitivity in Patients with Breast Cancer

Author:

Бармотько М.А.

Abstract

Представлен обзор литературы, посвященный изучению значимости состояния гена ТОР2А как фактора прогноза исхода заболевания и эффективности лечения антрациклинами у пациентов с раком молочной железы.A literature review was presented and devoted to study of significance gene TOP2A state as a factor in predicting the outcome of the disease and the efficacy of anthracyclines treatment in patients with breast cancer.

Publisher

Professionals Publications

Reference31 articles.

1. Okeanov A.E., Moiseev P.I., Levin L.F., Evmenenko A.A., Ipatij T.B. (2019) Rak v Belarusi: cifry i fakty. Analiz dannyh belorusskogo kancer-registra za2009–2018 gg. [Cancer in Belarus: facts and figures. Analysis of the data of the Belarusian Cancer Register for 2009-2018]. Minsk: Nacional'naya biblioteka Belarusi, 422 p.

2. Järvinen T.A. (1998) Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. Br. J. Cancer, vol. 77, no 12, pp. 2267–2273.

3. Di Leo A. (2002) HER-2 amplification and topoisomerase II gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin. Cancer Res, vol. 8, no 5, pp. 1107–1116.

4. Coon J.S. (2002) Amplification and overexpressionof topoisomerase II alpha predict response to anthracycline-based therapyin locally advanced breast cancer. Clin. Cancer Res, vol. 8, no 4, pp. 1061–1067.

5. Park K. (2002) Interaction between HER-2/neu and topoisomerase IIα amplification in preoperative doxorubicin-based chemotherapyfor locally advanced breast cancer: integration of novel chromogenic insitu hybridization and tissue microarray technology. Eur. J. Cancer, vol. 38, suppl. 3. S52.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3