Therapeutic Advances in the Treatment of Glioblastoma: Rationale and Potential Role of Targeted Agents-Reference-Cited by-全球学者库

Therapeutic Advances in the Treatment of Glioblastoma: Rationale and Potential Role of Targeted Agents

Published:2006-02-01 Issue:2 Volume:11 Page:152-164
ISSN:1083-7159
Container-title:The Oncologist
language:en
Short-container-title:

Author:

Reardon David A.¹,Wen Patrick Y.²

Affiliation:

1. a Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina, USA

2. b Center for NeuroOncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA

Abstract

Learning Objectives After completing this course, the reader will be able to: Describe the genetic alterations frequently observed in GBM tumors as well as the cell signal transduction pathways that are aberrantly activated in these tumors.Discuss the clinical benefit recently associated with temozolomide chemotherapy for patients with GBM.Identify mediators of signal transduction pathways that are attractive targets of novel therapeutics in GBM patients.Understand the potential benefit associated with regionally administered therapies for GBM patients as a means to overcome drug delivery limitations into the central nervous system caused by the blood–brain barrier.Describe the rationale for combination regimens incorporating novel targeted agents for GBM patients. CME Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.11-2-152

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