Minimizing Cardiotoxicity While Optimizing Treatment Efficacy with Trastuzumab: Review and Expert Recommendations

Author:

Martín Miguel1,Esteva Francisco J.2,Alba Emilio3,Khandheria Bijoy4,Pérez-Isla Leopoldo5,García-Sáenz José Ángel1,Márquez Antonia3,Sengupta Partho4,Zamorano José5

Affiliation:

1. a Department of Medical Oncology, San Carlos University Hospital, Madrid, Spain

2. b MD Anderson Cancer Center, Houston, Texas, USA

3. c Department of Oncology, Vírgen de la Victoria University Hospital, Málaga, Spain

4. d Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona, USA

5. e Department of Cardiology, San Carlos University Hospital, Madrid, Spain

Abstract

Learning Objectives Analyze the clinical trial data for the treatment of breast cancer. Evaluate the risk of cardiotoxicity associated with the use of trastuzumab. Design and conduct a practical approach to managing patients with trastuzumab-associated cardiotoxicity. This article is available for continuing medical education credit at CME.TheOncologist.com.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference56 articles.

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2. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer;Slamon;Science,1989

3. Basic science of HER-2/neu: A review;Hung;Semin Oncol,1999

4. Humanization of an anti-p185HER2 antibody for human cancer therapy;Carter;Proc Natl Acad Sci U S A,1992

5. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin);Sliwkowski;Semin Oncol,1999

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