Affiliation:
1. School of Sciences, Gujarat University
Abstract
Cancer stem cells (CSCs) also known as tumor initiating cells, are pluripotent and self-renewing subpopulation of cancer cells. This subpopulation is heterogeneous in nature which includes quiescent population and a proliferative population. Since CSCs were first identified in leukemia, their importance in chemoresistance, radioresistance, metastasis and recurrence were explored in detail through many studies. Different transcription factors like OCT4, SOX2, NANOG, KLF4, and c-Myc, as well as many signaling pathways like Wnt, Notch, NF-κB, Hedgehog and JAK/STAT are important regulators of CSCs. In addition different cells of tumor microenvironment, hypoxic condition, extracellular matrix and many miRNAs also regulate CSCs. This review summarizes model of CSC, properties and characterization CSC, and factors that regulate CSC. Figure 1 - Graphical abstract
Cited by
1 articles.
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