Low Circulating Levels of IGF-1 in Healthy Adults Are Associated With Reduced β-Cell Function, Increased Intramyocellular Lipid, and Enhanced Fat Utilization During Fasting-Reference-Cited by-同舟云学术

Low Circulating Levels of IGF-1 in Healthy Adults Are Associated With Reduced β-Cell Function, Increased Intramyocellular Lipid, and Enhanced Fat Utilization During Fasting

Published:2014-06-01 Issue:6 Volume:99 Page:2198-2207
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Thankamony Ajay¹,Capalbo Donatella¹,Marcovecchio M. Loredana¹,Sleigh Alison²,Jørgensen Sine Wanda³,Hill Nathan R.⁴,Mooslehner Katrin¹,Yeo Giles S. H.⁵,Bluck Les⁶,Juul Anders⁷,Vaag Allan³,Dunger David B.⁸

Affiliation:

1. Department of Paediatrics (A.T., D.C., M.L.M., K.M., D.B.D.), Cambridge, United Kingdom

2. Wolfson Brain Imaging Centre (A.S.), University of Cambridge, CB2 0QQ, Cambridge, United Kingdom

3. Department of Endocrinology (S.W.J., A.V.), Rigshospitalet and Copenhagen University, DK-2100 Denmark

4. Oxford Centre for Diabetes, Endocrinology, and Metabolism (N.R.H.), University of Oxford, Oxford, OX3 7LE, United Kingdom

5. Medical Research Council (MRC) Metabolic Diseases Unit (G.S.H.Y.), University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom

6. MRC Human Nutrition Research of Growth and Reproduction (L.B.); CB1 9NL, United Kingdom

7. Department of Growth and Reproduction (A.J.), Rigshospitalet, Faculty of Health and Medical Sciences, DK-2100 Denmark

8. National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre (D.B.D.), Cambridge, CB1 9NL, United Kingdom

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/99/6/2198/9049901/jcem2198.pdf

Reference41 articles.

1. Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1;LeRoith;Nat Clin Pract Endocrinol Metab,2007

2. β-Cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass;Kulkarni;Nat Genet,2002

3. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk;Dupuis;Nat Genet,2010

4. The association between IGF-I and insulin resistance: a general population study in Danish adults;Friedrich;Diabetes Care,2012

5. Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance;Sesti;Diabetes Care,2005

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