Adrenocortical Carcinoma

Author:

Else Tobias1,Kim Alex C.2,Sabolch Aaron3,Raymond Victoria M.1,Kandathil Asha32,Caoili Elaine M.32,Jolly Shruti3,Miller Barbra S.2,Giordano Thomas J.132,Hammer Gary D.1

Affiliation:

1. MEND/Division of Metabolism, Endocrinology, and Diabetes (T.E., T.J.G., G.D.H.), Division of Molecular Medicine and Genetics (V.M.R.), Department of Internal Medicine; University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109

2. Division of Endocrine Surgery (B.S.M.), Section of General Surgery, (A.C.K.), Department of Surgery, University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109

3. Departments of Radiation Oncology (A.S., J.S.), Pathology (T.J.G.), and Radiology (A.K., E.M.C.); University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109

Abstract

Abstract Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable prognosis. Here we summarize the knowledge about diagnosis, epidemiology, pathophysiology, and therapy of ACC. Over recent years, multidisciplinary clinics have formed and the first international treatment trials have been conducted. This review focuses on evidence gained from recent basic science and clinical research and provides perspectives from the experience of a large multidisciplinary clinic dedicated to the care of patients with ACC.

Publisher

The Endocrine Society

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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