Sorafenib-Induced Hypothyroidism Is Associated with Increased Type 3 Deiodination

Author:

Abdulrahman Randa M.1,Verloop Herman1,Hoftijzer Hendrieke1,Verburg Erik2,Hovens Guido C.1,Corssmit Eleonora P.1,Reiners Christoph2,Gelderblom Hans3,Pereira Alberto M.1,Kapiteijn Ellen3,Romijn Johannes A.1,Visser Theo J.4,Smit Johannes W.1

Affiliation:

1. Departments of Endocrinology and Metabolism (R.M.A., H.V., H.H., G.C.H., E.P.C., A.M.P., J.A.R., J.W.S.) Leiden University Medical Center, 2300 RC Leiden, The Netherlands;

2. Department of Nuclear Medicine (E.V., C.R.), University of Würzburg, D-97070 Würzburg, Germany;

3. Departments of Oncology (H.G., E.K.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands;

4. Department of Internal Medicine (T.J.V.), Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors.;Desai;Ann Intern Med,2006

2. A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake.;Mannavola;J Clin Endocrinol Metab,2007

3. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib.;Rini;J Natl Cancer Inst,2007

4. Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity.;Wong;Thyroid,2007

5. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib.;Chu;Lancet,2007

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