Increased Apolipoprotein AI Production Rate and Redistribution of High-Density Lipoprotein Size Induced by Estrogen plus Progestin as Oral Contraceptive

Author:

Duvillard Laurence1,Dautin Guillaume1,Florentin Emmanuel12,Jeannin Aline1,Pais de Barros Jean-Paul1,Lagrost Laurent1,Petit Jean-Michel13,Gambert Philippe12,Vergès Bruno13

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale Unité 866-Université de Bourgogne (L.D., G.D., E.F., A.J., J.-P.P.d.B., L.L., J.-M.P., P.G., B.V.), Faculté de Médecine, Dijon F-21000, France

2. Institut Fédératif de Recherche 100 (E.F., P.G.), Faculté de Médecine, Dijon F-21000, France

3. Department of Endocrinology and Metabolic Diseases (J.-M.P., B.V.), Centre Hospitalier Universitaire Dijon, Hôpital du Bocage, Dijon F-21000, France

Abstract

Context: The impact of estrogen plus progestin as an oral contraceptive on high density lipoprotein (HDL) apolipoprotein (apo) AI metabolism in humans is poorly understood.Objectives: This study was designed to measure the in vivo effect of Moneva (30 μg ethinylestradiol, 75 μg gestodene) on HDL apoAI production rate and fractional catabolic rate.Design: Using 13C-leucine, we performed two kinetic studies in the fed state in 10 normolipidemic young women, before and 3 months after beginning Moneva.Results: On Moneva, serum triglycerides increased by 12% (P = 0.03) in the fed state, whereas low-density lipoprotein and HDL cholesterol remained unchanged. HDL apoAI pool size and production rate were increased by 9.2% (67.3 ± 7.1 vs. 61.6 ± 6.7 mg · kg−1; P = 0.05) and 26.5% (14.3 ± 2.7 vs. 11.3 ± 2.2 mg · kg−1 · d−1; P = 0.02), respectively. HDL apoAI fractional catabolic rate was not significantly modified. Three-month treatment by Moneva induced a shift of HDL size distribution from HDL2 toward HDL3 (HDL3 = 51.5 ± 8.1 vs. 46.5 ± 9.2% of total HDL; P = 0.02) and an increase in the proportion of apoAI among HDL components (38.8 ± 4.3 vs. 34.4 ± 2.8%; P = 0.01).Conclusion: Oral contraception by estrogen plus progestin induces changes in HDL apoAI metabolism characterized by an increase in production rate and pool size, with a higher proportion of HDL3 particles. Whether or not these changes are beneficial to prevent atherosclerosis has to be explored further.

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

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