Affiliation:
1. Division of Pediatric Endocrinology, Diabetes, and Metabolism, Department of Pediatrics (S.E.O., A.B.S., A.T.G.), Columbia University Medical Center, New York, New York 10032
Abstract
Premature pubarche, or the development of pubic hair before the age of 8 in girls or 9 in boys, is most commonly caused by premature adrenarche. Adrenarche is the maturation of the adrenal zona reticularis in both boys and girls, resulting in the development of pubic hair, axillary hair, and adult apocrine body odor. Although originally thought to be a benign variant of normal development, premature adrenarche has been associated with insulin resistance and the later development of metabolic syndrome and polycystic ovary syndrome. Although further studies are needed to confirm these relationships, the case presented herein argues for periodic assessment of children at risk. Indeed, recognition of these associations may allow for early preventive measures.
Subject
Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism
Reference103 articles.
1. The prepubertal and pubertal growth of the adrenal (adrenarche).;Dhom;Beitr Pathol,1973
2. Precocious growth of sexual hair without other secondary sexual development: “premature pubarche,” a constitutional variation of adolescence.;Silverman;Pediatrics,1952
3. Premature pubarche.;Sigurjonsdottir;Clin Pediatr (Phila),1968
4. Precocious thelarche and premature adrenarche predictors.;Pang;Pediatr Ann,1981
5. Premature adrenarche.;Pang;Pediatr Adolesc Endocrinol,1984
Cited by
58 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献