Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice

Author:

Selvaraj Uma Maheswari1,Zuurbier Kielen R1,Whoolery Cody W1,Plautz Erik J1,Chambliss Ken L2,Kong Xiangmei1,Zhang Shanrong3,Kim Sung Hoon4,Katzenellenbogen Benita S5,Katzenellenbogen John A4,Mineo Chieko2,Shaul Philip W2,Stowe Ann M16ORCID

Affiliation:

1. Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas

2. Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas

3. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas

4. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois

5. Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois

6. Department of Neurology, University of Kentucky, Lexington, Kentucky

Funder

National Heart, Lung, and Blood Institute

National Institute of Neurological Disorders and Stroke

National Institute of Diabetes and Digestive and Kidney Diseases

American Heart Association

Publisher

The Endocrine Society

Subject

Endocrinology

Reference79 articles.

1. Chronic and acute effects of oestrogens on vascular contractility;Austin;J Hypertens,2000

2. Paganini-Hill A . Estrogen replacement therapy: something to smile about. Compend Contin Educ Dent Suppl. 1998;(22):S4–S8.

3. Premature menopause is associated with increased risk of cerebral infarction in Japanese women;Baba;Menopause,2010

4. Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17β-estradiol;Leon;Endocrinology,2012

5. Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3β phosphorylation;Koh;Neurosci Lett,2006

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