Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress

Author:

Paddon-Jones Douglas1,Sheffield-Moore Melinda2,Cree Melanie G.1,Hewlings Susan J.1,Aarsland Asle13,Wolfe Robert R.1,Ferrando Arny A.1

Affiliation:

1. Departments of Surgery (D.P.-J., M.G.C., S.J.H., A.A., R.R.W., A.A.F.), Galveston, Texas 77550

2. Internal Medicine (M.S.-M.) Galveston, Texas 77550

3. Anesthesiology (A.A.), The University of Texas Medical Branch, Galveston, Texas 77550

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest;Paddon-Jones;J Clin Endocrinol Metab,2004

2. Protein synthesis and breakdown;Wolfe;In: Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis. New York: Wiley-Liss;,1992

3. Bed-rest-induced insulin resistance occurs primarily in the muscle;Stuart;Metabolism,1988

4. Inactivity amplifies the catabolic response of skeletal muscle to cortisol;Ferrando;J Clin Endocrinol Metab,1999

5. Effect of cortisol on energy expenditure and amino acid metabolism in humans;Brillon;Am J Physiol Endocrinol Metab,1995

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