Ghrelin and Leptin Pulse Discharge in Fed and Fasted Rats-Reference-Cited by-同舟云学术

Ghrelin and Leptin Pulse Discharge in Fed and Fasted Rats

Published:2002-02-01 Issue:2 Volume:143 Page:726-729
ISSN:0013-7227
Container-title:Endocrinology
language:en
Short-container-title:

Author:

Bagnasco Michela¹,Kalra Pushpa S.²,Kalra Satya P.¹

Affiliation:

1. Departments of Neuroscience (M.B., S.P.K.), College of Medicine, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610-0244

2. Physiology and Functional Genomics (P.S.K.), College of Medicine, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610-0244

Abstract

Abstract Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all parameters of ghrelin pulsatile secretion and diminished leptin secretion by selectively attenuating the pulse amplitude; concomitantly it produced synchrony in ghrelin and leptin pulse discharge. These studies imply that a synchronous leptin restraint and ghrelin stimulus on NPYergic signaling may underlie robust appetitive drive.

Publisher

The Endocrine Society

Subject

Endocrinology

Link

http://academic.oup.com/endo/article-pdf/143/2/726/10370142/endo0726.pdf

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